Dichloromethane → Butyl α-[[(1,1-dimethylethoxy)carbonyl]amino]-2-furanacetate

Participants

Reaction Steps

A solution of 1.6 g. (0.006 mol.) of N-t-butoxycarbonyl-2-acetoxyglycine n-butyl ester and 0.7 g. (0.01 mol.) of redistilled furan in 75 ml. of methylene chloride was cooled to -78° and four drops of boron trifluoride etherate was added with stirring. The reaction mixture was warmed to room temperature and left for three hours. Chromatography on silica gel with methylene chloride and methylene chloride containing increasing amounts of ethyl acetate gave the title compound.

Provenance & Evidence