反应详情

3-Amino-4-bromo-2,5-diisopropylbenzenesulfonamide is prepared by known general methods (L. F. Fieser and M. Fieser, Reinhold Publishing Corp., N. Y., 3rd ed., 1956, pgs 599-602) from 2,5-diisopropylaniline by acylation to 2,5-diisopropylacetanilide, bromination to 4-bromo-2,5-diisopropylacetanilide, hydrolysis to 4-bromo-2,5-diisopropylaniline, nitration to 4-bromo-2,5-diisopropyl-3-nitroaniline, diazotization in the presence of cuprous chloride and sulfur dioxide to 4-bromo-2,5-diisopropyl-3-nitrobenzenesulfonamide (method of Example 6) and reduction.