Sodium Cyanide → HCID 21492127, compound

HRID 1973547Notes

Reaction equation

HRID 1973547 reaction equation
Br[CH2:2][C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[CH:7][C:6]([S:12]([NH2:15])(=[O:14])=[O:13])=[C:5]([CH:16]([CH3:18])[CH3:17])[CH:4]=1.[C-:19]#[N:20].[Na+]>CS(C)=O>[C:19]([CH2:2][C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[CH:7][C:6]([S:12]([NH2:15])(=[O:14])=[O:13])=[C:5]([CH:16]([CH3:18])[CH3:17])[CH:4]=1)#[N:20]

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 21492138HCID 21492138, compound

Product 1

HCID 21492127HCID 21492127, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To 32 parts 4-bromomethyl-2,5-diisopropylbenzenesulfonamide in 100 parts dimethylsulfoxide is added 10 parts sodium cyanide. The reaction is heated at 65°-70° for 30 minutes and then poured into ice water to give 4-cyanomethyl-2,5-diisopropylbenzenesulfonamide. Purification is accomplished by recrystallization or chromatography on Florisil, silica gel, alumina, etc., but the relatively pure reaction product is useful in the compositions and methods of this invention without purification.

Workup

  1. temperatureThe reaction is heated at 65°-70° for 30 minutes

Sources & evidence

ORD record
ord-8d79f4f88c0d4f7cb383a2bba03aa290
Source dataset
uspto-grants-1976_12
Patent number
US03997603

Reaction notes

Loading…