HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → Ethyl alpha-[4-(3-oxo-isobenzofuran-1-ylamino)-phenyl]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Phthalaldehydic acid | HCID 8406 | — |
| Reactant | Ethyl 2-(4-aminophenyl)propanoate | HCID 118009 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl alpha-[4-(3-oxo-isobenzofuran-1-ylamino)-phenyl]propionate | HCID 70550907 | — |
Reaction Steps
The mixture of 17.7 g of ethyl α-(4-aminophenyl)-propionate, 15 g of 2-carboxy-benzaldehyde, 50 mg of p-toluenesulfonic acid and 400 ml of toluene is refluxed for two days on a water trap. After collection of the theoretical amount of water (1.9 ml), it is concentrated and the precipitate formed recrystallized from ethanol, to yield the ethyl α-[4-(3-oxo-isobenzofuran-1-ylamino)-phenyl]-propionate, melting at 136°-139°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03997669 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-be0f3ca7098c4a48a367afb70379638a |
| Source note | uspto-grants-1976_12 |