HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium ethoxide → 4-(4-n-Heptylpyrimid-2-yl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Benzoic acid, 4-(aminoiminomethyl)-, ethyl ester, hydrochloride (1:1) | HCID 12710118 | — |
| Reactant | 3-Ethoxy-2-heptylacrolein | HCID 54239824 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(4-n-Heptylpyrimid-2-yl)-benzoic acid | HCID 20379674 | — |
| Product | 4(4-n-Heptylpyrimid-2-yl)-benzoic acid ethyl ester | HCID 54371941 | — |
Reaction Steps
A suspension of 0.1 mole of 4-amidino-benzoic acid ethyl ester hydrochloride, 0.1 mole of 2-n-heptyl-3-ethoxy-acrolein and 0.14 mole of sodium ethylate in 100 ml of methanol is stirred overnight at room temperature under an atmosphere of nitrogen. After the usual work up and separation into basic and acidic fractions, there is obtained 4-(4-n-heptylpyrimid-2-yl)-benzoic acid ethyl ester and 4-(4-n-heptylpyrimid-2-yl)-benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03997536 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-28d29e795aa742a5aab166cc4ae5a2bc |
| Source note | uspto-grants-1976_12 |