HCID 21388868, compound → 2-(4-Pentylphenyl)pyrimidine-5-carbonitrile

HRID 1973602Notes

Reaction equation

HRID 1973602 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:12][CH:11]=2)[N:3]=1>[Zn].O1CCOCC1>[C:8]([C:7]1[CH:2]=[N:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:12][CH:11]=2)=[N:5][CH:6]=1)#[N:9]

Participants

4

Reactant 1

HCID 21388868HCID 21388868, compound

Product 1

HCID 135748242-(4-Pentylphenyl)pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 312751,4-DioxaneSolvent

Procedure

6.3 G. of 4-chloro-5-cyano-2-(4-n-pentylphenyl)-pyrimidine are reacted in 290 ml. of 50% dioxane with 25.3 g. of pre-treated zinc dust and worked up after the reaction in a manner analogous to that described in Example 13. There is obtained 5-cyano-2-(4-n-pentylphenyl)-pyrimidine as colorless crystals having a melting point of 96.0°-96.2° C. and clearing point of 109.0° C. The substance is identical with the compound obtained according to Example 9.

Workup

  1. customafter the reaction in a manner analogous to

Sources & evidence

ORD record
ord-22d4e5e90f564724a46369b57c63fcea
Source dataset
uspto-grants-1976_12
Patent number
US03997536

Reaction notes

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