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Sodium Hydroxide → 4-Chloro-5-cyano-2-(4-heptyloxyphenyl)-pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | p-Heptyloxybenzamidine hydrochloride | HCID 12238503 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Chloro-5-cyano-2-(4-heptyloxyphenyl)-pyrimidine | HCID 21388806 | — |
反応手順
The starting material can be obtained according to the procedure of A. R. Todd and F. Bergel, J. Chem. Soc. 1937, 365 by reaction of p-n-heptyloxybenzamidine hydrochloride with α-ethoxymethylene-α-cyanoacetic acid ethyl ester and sodium ethylate in ethanol and then with sodium hydroxide solution. The resulting 5-cyano-4-hydroxy-2-(4-n-heptyloxphenyl)-pyrimidine (melting point 180.8° C; smectic up to 231.5° C. (clearing point)) is treated with phosphorus oxychloride to give 4-chloro-5-cyano-2-(4-heptyloxyphenyl)-pyrimidine having a melting point of 133.3°-134.6° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03997536 |
| 出典データセット | uspto-grants-1976_12 |
| ORD ID | ord-fee15190b7f74cddbee8610362ba37d6 |
| 出典メモ | uspto-grants-1976_12 |