HCID 86734274, compound → HCID 86734273, compound

HRID 1973622Notes

Reaction equation

HRID 1973622 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@@H:11]2[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[CH2:12]2)=[C:4]([Se:19][CH3:20])[N:3]=1>CCOC(C)=O.C1CCCCC1>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@H:11]2[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[CH2:12]2)=[C:4]([Se:19][CH3:20])[N:3]=1

Participants

3

Reactant 1

HCID 86734274HCID 86734274, compound

Product 1

HCID 86734273HCID 86734273, compound

Reagents, catalysts & solvents 1

HCID 21867204Cyclohexane ethylacetateSolvent

Procedure

The procedure was the same as that used for the synthesis of 7a except that 500 mg (0.0015 mol) of 2 was used and the yield from the EtOAc-cyclohexane mixture was 200 mg (39%) of product, mp 167°-170°. For analysis the sample was dried in vacuo over Drierite for 1 hr. at the temperature of refluxing toluene: mp unchanged; uv λmax (pH 1) 334 nm ( ε 14 400); uv λmax (MeOH) 313 nm ( ε 15 800); uv λmax (pH 11) 316 nm ( ε 15 500).

Workup

  1. dry with materialFor analysis the sample was dried in vacuo over Drierite for 1 hr

Sources & evidence

ORD record
ord-644ddcab3f024ae9a7c2579a33bd302a
Source dataset
uspto-grants-1976_12
Patent number
US03998806

Reaction notes

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