Ethanol → HCID 54306529, compound

Participants

Reaction Steps

1-(α-Chloroacetyl pyrrolidine (14.7 grams; 0.1 mol), potassium thiocyanate (18 grams; 0.2 mol) and ethanol (50 ml) were charged into a glass reaction flask equipped with a mechanical stirrer and reflux condenser. The reaction mixture was heated at reflux, with stirring, for a period of about 4 hours. The mixture was then cooled and filtered. The filtrate was stripped of solvent to yield a solid product. The solid was extracted with three 200 ml portions of boiling benzene, and the benzene extracts were combined and evaporated under reduced pressure to yield an oil. The oil was poured into pentane wherein it solidified. The solid was recrystallized from a benzene-pentane mixture to yield 1-(α-thiocyanoacetyl) pyrrolidine having a melting point of 95° to 96° C. and having the following elemental analysis; calculated for C7H10N2OS.

Provenance & Evidence