Sodium Iodide → HCID 21490111, compound

Participants

Reaction Steps

1-(α-Chloroacetyl)-2,5-dimethylpyrrolidine (10 grams; 0.057 mol), potassium thiocyanate (10.1 grams), sodium iodide (a few crystals) and ethanol (100 ml) were charged into a glass reaction flask equipped with mechanical stirrer and reflux condenser. The reaction mixture was heated at reflux, with stirring, for a period of about 2 hours. After this time the reaction mixture was cooled and filtered. The filtrate was stripped of ethanol under reduced pressure resulting in a solid product. The solid was extracted with two 125 ml portions of hot benzene. The benzene extracts were combined and were evaporated to yield 1-(α-thiocyanoacetyl)-2,5-dimethylpyrrolidine as a light brown oil having a refractive index at 25° C. of 1.5185 and having the following elemental analysis as calculated for C9H14N2OS.

Provenance & Evidence