Potassium thiocyanate → HCID 54155438, compound

HRID 1973631Notes

Reaction equation

HRID 1973631 reaction equation
Cl[CH2:2][CH2:3][C:4]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5].[S-:11][C:12]#[N:13].[K+]>C(O)C>[S:11]([CH2:2][CH2:3][C:4]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[C:12]#[N:13]

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 32712661-(3-CHLOROPROPANOYL)PYRROLIDINE

Product 1

HCID 54155438HCID 54155438, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-(β-Chloropropionyl) pyrrolidine (16 grams; 0.1 mol), potassium thiocyanate (18 grams; 0.2 mol) and ethanol (100 ml) are charged into a glass reaction flask equipped with a mechanical stirrer and reflux condenser. The reaction mixture is then heated at reflux for a period of about 6 hours. After this time the reaction mixture is cooled and filtered. The filtrate is stripped of solvent and the residue is extracted with benzene. The benzene extract is evaporated under reduced pressure to yield 1-(β-thiocyanopropionyl) pyrrolidine as a residue.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is then heated
  4. temperatureat reflux for a period of about 6 hours
  5. temperatureAfter this time the reaction mixture is cooled
  6. filtrationfiltered
  7. extractionthe residue is extracted with benzene
  8. extractionThe benzene extract
  9. customis evaporated under reduced pressure

Sources & evidence

ORD record
ord-7a66f3532b734bfc87c1ddce421c0ab0
Source dataset
uspto-grants-1976_12
Patent number
US03998808

Reaction notes

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