Morpholine → HCID 21548161, compound

HRID 1973653Notes

Reaction equation

HRID 1973653 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5](Cl)=[C:4]2[CH:9]=[N:10][C:11]([CH3:15])=[C:12]([O:13][CH3:14])[C:3]=12.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[CH3:15][C:11]1[N:10]=[CH:9][C:4]2=[C:5]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[N:6]=[N:7][C:2]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[C:3]2[C:12]=1[O:13][CH3:14]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 21548163HCID 21548163, compound

Product 1

HCID 21548161HCID 21548161, compound

Procedure

0.5 parts by weight of 1,4-dichloro-7-methyl-8-methoxypyrido (3,4-d) pyridazine and 3.6 parts by weight of morpholine are heated together at 80° C for 1.5 hours and, then, the excess morpholine is distilled off. To the residue is added water, whereupon an oily precipitate is obtained. This oil is triturated with a small amount of methanol to obtain crystals of 7-methyl-8-methoxy-1,4-dimorpholinopyrido (3,4-d)-pyridazine. Recrystallization from a mixture of methanol and water (1:3) yields crystals melting at 145°-146° C. Yield 0.5 parts by weight. Elementary analysis for C17H24O3N5

Workup

  1. distillationthe excess morpholine is distilled off
  2. additionTo the residue is added water
  3. customwhereupon an oily precipitate is obtained
  4. customThis oil is triturated with a small amount of methanol

Sources & evidence

ORD record
ord-433dd58413064ce799d441c7eca4e5a8
Source dataset
uspto-grants-1976_12
Patent number
US03998822

Reaction notes

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