Morpholine → HCID 12246656, compound

HRID 1973655Notes

Reaction equation

HRID 1973655 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5](Cl)=[C:4]2[C:9]([CH3:21])=[N:10][C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)=[CH:12][C:3]=12.[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]2[N:10]=[C:9]([CH3:21])[C:4]3=[C:5]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)[N:6]=[N:7][C:2]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[C:3]3[CH:12]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 12246634HCID 12246634, compound

Product 1

HCID 12246656HCID 12246656, compound

Conditions

Temperature
130 °C

Procedure

1.0 part by weight of 1,4-dichloro-7-(p-methoxyphenyl)-5-methylpyrido(3,4-d)pyridazine is added to 10 parts by volume of morpholine, and the resulting mixture is heated at 130° C for 3 hours. The excess amount of morpholine is removed by evaporating under reduced pressure, and water is added to the residue. The crude crystals are collected by filtration and recrystallized from ethanol to obtain 7-(p-methoxyphenyl)-5-methyl-1,4-dimorpholinopyrido(3,4-d)-pyridazine as gray prisms melting at 206° to 209° C. Elementary analysis for C23H27O3N5

Workup

  1. customThe excess amount of morpholine is removed
  2. customby evaporating under reduced pressure, and water
  3. additionis added to the residue
  4. filtrationThe crude crystals are collected by filtration
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-940a4630662546af96098d2f4e51a892
Source dataset
uspto-grants-1976_12
Patent number
US03998822

Reaction notes

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