Tert-Butylamine → (S)-3-(tert-Butylamino)propane-1,2-diol

Participants

Reaction Steps

30 g of (R)-glyceraldehyde, 36 cc of tert. butylamine in 800 cc of ethanol are hydrogenated over 8 g of 10 % palladium/carbon with H2 for 4 hours, the catalyst is filtered off and the solution is concentrated. (S)-1-tert.butylamino-2,3-dihydroxy-propane is obtained from ethyl acetate/ether (2:1) in the form of crystals having a M.P. of 76°-81°. [α] 20546 = -11.8° (c = 2.0; methanol).

Provenance & Evidence