HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → (S)-3-tert. butyl-5-hydroxy-methyl-2-phenyloxazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Benzene | HCID 241 | — |
| Reactant | (S)-3-(tert-Butylamino)propane-1,2-diol | HCID 2733671 | — |
| Solvent | Water | HCID 962 | — |
| Product | (S)-3-tert. butyl-5-hydroxy-methyl-2-phenyloxazolidine | HCID 86734277 | — |
Reaction Steps
22 g of (S)-1-tert.butylamino-2,3-dihydroxypropane, 20.7 g of benzaldehyde and 46 cc of benzene are heated at reflux in a water separator for 16 hours. The benzene and benzaldehyde are removed by distillation and the residue is distilled in a high vacuum. (S)-3-tert. butyl-5-hydroxy-methyl-2-phenyloxazolidine is obtained as yellowish oil (B.P. 110°-125° at 0.01 mm of Hg); [α]20546 = 17.8° (c = 1.99; chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03998835 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-87237c1e6f21415095e22b72680f230e |
| Source note | uspto-grants-1976_12 |