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HRID1973708

反应详情

EQUATION

反应方程式

HRID 1973708 的结构方程式

REACTANTS

反应物

2
结构：C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID10133

Chenodeoxycholic acid

C24H40O4

结构：C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
HCID221493

Cholic acid

C24H40O5

2 次

PRODUCTS

生成物

1
结构：COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
HCID10960835

(3alpha,5beta,7alpha,12alpha)-Cholan-24-oic acid methyl ester

C25H42O5

PROCEDURE

实验过程

A process for preparing chenodeoxycholic acid from cholic acid comprising the steps of: (1) esterification of the acid group of the cholic acid to produce methyl cholate; (2) selective acetylation of the methyl cholate to produce methyl 3,7-diacetyl cholate; (3) mesylation of the methyl 3,7-diacetyl cholate to produce methyl 3,7-diacetyl-12-mesylcholate; (4) dehydromesylation of the methyl 3,7-diacetyl-12-mesylcholate by hexamethylphosphoric triamide in the presence of a weak base to produce methyl 3,7-diacetylchol-11-enate; (5) hydrogenation of the methyl 3,7-diacetylchol-11-enate to produce methyl diacetyl chenodeoxycholate; and (6) saponification of the methyl diacetyl chenodeoxycholate to produce chenodeoxycholic acid.