HuagongsheHuagongshe Chemistry Print Report · For research reference only
21-Methyl-5alpha-pregnane-3,11,20-trione → 3alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 21-Methyl-5alpha-pregnane-3,11,20-trione | HCID 131710575 | — |
| Catalyst | Tetrachloroiridium--hydrogen chloride--water (1/2/1) | HCID 16211483 | — |
| Product | 3alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione | HCID 86734287 | — |
Reaction Steps
21-Methyl-5α-pregnane-3,11,20-trione (0.4 g.) was added to "stock" chloroiridic acid solution (75 ml.) and the resulting mixture was refluxed for 2 hr. The solution was then cooled and partitioned between water and ether. The organic layer was washed with saturated aqueous sodium bicarbonate, dried (Na2SO4) and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03998829 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-74f27b354f7046d6a5fd64635496c2cf |
| Source note | uspto-grants-1976_12 |