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HRID1973729

反应详情

EQUATION

反应方程式

HRID 1973729 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：C=CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID86734286

未命名化合物

结构：OC(=S)CN1CCCCC1
HCID178526201

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CC[C@@H](O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)CCSC(=O)CN4CCCCC4)[C@@]3(C)CC(=O)[C@@H]12
HCID86734298

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A solution of 3α-hydroxy-21-methylene-5α-pregnane-11,20-dione (350 mg) in acetone (15 ml) was refluxed with piperidinothioacetic acid for 1/2 hour, poured into water and the suspension extracted into ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulphate and evaporated to give title compound (400 mg) as a white foam. [α]D + 50° (c = 0.19 ).

WORKUP

后处理

  1. extractionthe suspension extracted into ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous sodium sulphate
  4. customevaporated