HCID 86734286、化合物 → 3alpha-Hydroxy-21-nicotinylthiomethyl-5alpha-pregnane-11,20-dione
反応式
[OH:1][C@@H:2]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:19]2[C:18](=[O:24])[CH2:17][C@@:16]2([CH3:25])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:15])[CH:13]=[CH2:14])[CH2:3]1.[C:26](O)(=[S:33])[C:27]1[CH:32]=[CH:31][CH:30]=[N:29][CH:28]=1>CC(C)=O>[OH:1][C@@H:2]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:19]2[C:18](=[O:24])[CH2:17][C@@:16]2([CH3:25])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:15])[CH2:13][CH2:14][S:33][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[N:29][CH:28]=2)[CH2:3]1参加物
4
実験手順
Treatment of 3α-hydroxy-21-methylene-5α-pregnane-11,20-dione (240 mg) in acetone (15 ml) with thionicotinic acid (150 mg) for 4 hrs. in similar manner to that described in Example 27 gave title compound (220 mg) as a white foam [αD ] + 55.6° (c 1.01).