Sodium Iodide → HCID 86734302, compound

Participants

Reaction Steps

21-Chloroacetoxymethyl-3α-hydroxy-5α-pregnane-11,20-dione (400 mg.) in acetone (40 ml) was treated with sodium iodide (420 mg.) and the mixture was refluxed for 40 mins. The filtered solution was evaporated to a yellow solid which was partitioned between water and ether/ethyl acetate 1:1. The organic layer was washed with water, dried over sodium sulphate and evaporated to give title compound (500 mg) as a yellow foam.

Provenance & Evidence