反应详情

A mixture of 3.1 parts of 2-bromoethylbenzene, 4.1 parts of N-[4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide, 0.1 parts of potassium iodide, 2.4 parts of sodium carbonate and 80 parts of 4-methyl-2-pentanone is stirred and refluxed for 48 hours. The reaction mixture is poured onto water and the whole is shaken thoroughly. The organic phase is separated, washed with water, dried, filtered and evaporated. The oily residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The oily residue solidifies on triturating in n-hexane. The product is filtered off and dried, yielding N-[4-(methoxymethyl)-1-(2-phenylethyl)-4-piperidinyl]-N-phenylpropanamide; mp. 85° C.

1. temperaturerefluxed for 48 hours
2. additionThe reaction mixture is poured onto water
3. stirringthe whole is shaken thoroughly
4. customThe organic phase is separated
5. washwashed with water
6. customdried
7. filtrationfiltered
8. customevaporated
9. customThe oily residue is purified by column-chromatography over silica gel using
10. additiona mixture of trichloromethane and 5% of methanol as eluent
11. customThe pure fractions are collected
12. customthe eluent is evaporated
13. customon triturating in n-hexane
14. filtrationThe product is filtered off
15. customdried