HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 21490646, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(4-Ethylphenyl)quinazolin-4(1H)-one | HCID 135604695 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21490646 | HCID 21490646 | — |
Reaction Steps
A mixture of 7.43 g of 2-(4-ethylphenyl)quinazolin-4(3H)-one and 50 ml of thionyl chloride was treated with 2.17 g of dimethylformamide as described in Example I. The solid was recrystallized twice from petroleum ether (60°-110° fraction) to give 4.23 g of light-colored 4-chloro-2-(4-ethylphenyl)quinazoline, m.p. 75.5°-76.5°; ir and nmr spectra were consistent with the assigned structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03998951 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-fae512bd42724248b0b1c9a158f3d6c2 |
| Source note | uspto-grants-1976_12 |