HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 21490645, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(2-methylphenyl)quinazolin-4(3H)-one | HCID 135677600 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21490645 | HCID 21490645 | — |
Reaction Steps
A mixture of 7.6 g of 2-(2-methylphenyl)quinazolin-4(3H)-one and 55 ml of thionyl chloride was treated with 2.35 g of dimethylformamide as described in Example I. The isolated solid was recrystallized from cyclohexane to give 5.1 g of 4-chloro-2-(2-methylphenyl)quinazoline, m.p. 103°-104°; ir and nmr spectra were consistent with the assigned structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03998951 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-988a7e7a174e45c39ea37e88c3f6c9b1 |
| Source note | uspto-grants-1976_12 |