HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloroaniline → 2-(3-Chlorophenyl)-5,6,7,8-tetrahydro-1,3(2H,4H)-isoquinolinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloroaniline | HCID 7932 | — |
| Reactant | HCID 131710580 | HCID 131710580 | — |
| Product | 2-(3-Chlorophenyl)-5,6,7,8-tetrahydro-1,3(2H,4H)-isoquinolinedione | HCID 21490751 | — |
Reaction Steps
A mixture of tetrahydrohomophthalic acid (46.0 g., 0.25 mole) and m-chloroaniline (31.8 g., 0.25 mole) is heated by an oil bath until molten for two hours. When removed from the oil bath, the reaction mixture solidifies and is recrystallized twice from ethanol/ethyl acetate, giving 2-(m-chlorophenyl)-5,6,7,8-tetrahydroisoquinoline-1,3(2H,4H)-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03998954 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-196176be78b44da582cf748758510b51 |
| Source note | uspto-grants-1976_12 |