Methyl Isocyanate → N-(7-Methoxy-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)-N'-methylurea

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Reaction Steps

Crude 4,5,6,7-tetrahydro-7-methoxybenzo[b]thiophen-4-amine (2.3 g, 12.57 mm) is dissolved in ether (50 ml) and the stirred solution treated with a solution of methyl isocyanate (2.9 ml) in ether (10 ml), added over a period of 20 minutes. After stirring overnight the product is filtered off, washed twice with ether (50 ml total) and air dried to afford the title compound (2.25 g, 75% Y) m.p. 152° C-159° C. The analytical sample is recrystallized from acetone and has m.p. 164° C-166° C.

Provenance & Evidence