4-Fluorophenyl isocyanate → HCID 54010928, compound

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Reaction Steps

To a solution of 4.9 g. (0.05 mole) of 2 -imino-1 -methylpyrrolidine in anhydrous benzene is added 6.85 g. (0.05 mole) of p-fluorophenylisocyanate, dissolved in anhydrous benzene, dropwise with stirring. The mixture is stirred at room temperature overnight, then filtered and the filtrate taken to dryness in vacuo. The residue is triturated with isopropanol. The solid which forms is collected, 1 -p-fluorophenyl-3 -(1 -methyl-2 -pyrrolidylidene)urea, m.p. = 113°-115° C. Recrystallization from ethyl acetate yields the pure product, m.p. = 115°-116° C.

Provenance & Evidence