Tetrafluoroborate → 1-(1-Benzyl-2-pyrrolidylidene)-3-(3-chloro-4-fluorophenyl)urea

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Reaction Steps

The fluoroborate salt of 1-benzyl-2-iminopyrrolidine (6.55 g.; 0.025 mole) is converted to the free base (4.36 g.; 0.025 mole) in the usual manner. After drying over K2CO3, the benzene solution is filtered through diatomaceous earth and 4.29 g. (0.025 mole) of 3-chloro-4-fluorophenyl-isocyanate is added. The reaction mixture is stirred at room temperature for 1 hour and then evaporated to dryness in vacuo to give a solid residue. Recrystallizations from acetone-ether yields the pure product, 1-(1-benzyl-2-pyrrolidylidene)- 3-(3-chloro-4-fluorophenyl)urea, m.p. = 131°-132° C.

Provenance & Evidence