Diisopropylamine → 8-Quinolinecarbothioamide, 2-ethyl-5,6,7,8-tetrahydro-

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Reaction Steps

By the method described in Example 11 using di-isopropylamine (2 ml 0.014 mol) in benzene (20 ml), n-butyl lithium solution (9% w/v, 10 ml, 0.014 mol), 2-ethyl-5,6,7,8-tetrahydroquinoline (2.3 g, 0.014 mol) and trimethylsilyl isothiocyanate (2 ml 0.015 mol) was obtained 2-ethyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide (600 mg, 20%) m.p. 73-5° C (Found: C, 65.25; H, 7.6; N, 12.75. C12H16N2S requires C, 65.4; H, 7.3; N, 12.7%).

Provenance & Evidence