HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 8-Quinolinecarbothioamide, 5,6,7,8-tetrahydro-3,4-dimethyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | Isothiocyanatotrimethylsilane | HCID 75297 | — |
| Reactant | Quinoline, 5,6,7,8-tetrahydro-3,4-dimethyl- | HCID 12278208 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 8-Quinolinecarbothioamide, 5,6,7,8-tetrahydro-3,4-dimethyl- | HCID 12278220 | 5.3% |
Reaction Steps
By the method described in Example 11 using di-isopropylamine (4.9 ml 0.034 mol) in benzene (50 ml), n-butyl lithium solution (9% w/v, 25 ml, 0.034 mol), 3,4-dimethyl-5,6,7,8-tetrahydroquinoline (5.65g, 0.034 mol) and trimethylsilyl isothiocyanate (4.9 ml, 0.038 mol) was obtained 3,4-dimethyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide (0.4 g, 5%) m.p. 163-5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04000142 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-3ab5657469b84ed4a8944b4cc65d935b |
| Source note | uspto-grants-1976_12 |