HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-amino-2,4-dihydro-4-methyl-2-phenyl-3H-pyrazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 22755148 | HCID 22755148 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 5-amino-2,4-dihydro-4-methyl-2-phenyl-3H-pyrazol-3-one | HCID 93880 | — |
Reaction Steps
A solution of 261 g (1 mole) of 1-phenyl-3-carbethoxyamino-4-methyl-2-pyrazolin-5-one in 1600 ml of 2.5 N sodium hydroxide was refluxed for 30 min. The solution was cooled and neutralized by addition of 250 ml of concentrated hydrochlorid acid and 50 ml of glacial acetic acid. The precipitate was separated and dried. Yield: 160 g (84%). Melting point: 147° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04000156 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-be51c15903364dcc9c236a49bd109af3 |
| Source note | uspto-grants-1976_12 |