HCID 21488574, compound → HCID 21488619, compound

HRID 1974057Notes

Reaction equation

HRID 1974057 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:12](C)=[N:13][N:14]=[C:7]1[CH:6]=[C:5]2[C:16]1[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=1[F:23].I([O-])(=O)(=O)=[O:25].[Na+]>[Ru](=O)=O>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([N:8]2[CH:12]=[N:13][N:14]=[C:7]2[CH3:6])=[C:4]([CH:3]=1)[C:5]([C:16]1[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=1[F:23])=[O:25]

Participants

4

Reactant 2

HCID 21488574HCID 21488574, compoundHCID 23667635Sodium periodate

Product 1

HCID 21488619HCID 21488619, compound

Reagents, catalysts & solvents 1

HCID 82848Ruthenium dioxideCatalyst

Procedure

In the manner given in Example 3, 7-chloro-1-methyl-5-(2,6-difluorophenyl)-s-triazolo[4,3-a]quinoline is oxidized at low temperature with sodium periodate and ruthenium dioxide to give 5-chloro-2',6'-difluoro-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone.

Sources & evidence

ORD record
ord-acf7de1620f9420aab90a79e75932cbb
Source dataset
uspto-grants-1976_12
Patent number
US04000151

Reaction notes

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