[1,2,4]Triazolo[4,3-a]quinoline, 7-chloro-5-phenyl- → HCID 12246022, compound

HRID 1974080Notes

Reaction equation

HRID 1974080 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[N:13][N:14]=[C:7]1C=[C:5]2[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.I([O-])(=O)(=O)=[O:22].[Na+]>[Ru](=O)=O>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([N:8]2[CH:12]=[N:13][N:14]=[CH:7]2)=[C:4]([CH:3]=1)[C:5]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:22]

Participants

4

Reactant 2

HCID 12246499[1,2,4]Triazolo[4,3-a]quinoline, 7-chloro-5-phenyl-HCID 23667635Sodium periodate

Product 1

HCID 12246022HCID 12246022, compound

Reagents, catalysts & solvents 1

HCID 82848Ruthenium dioxideCatalyst

Procedure

In the manner given in Example 3, 7-chloro-5-phenyl-s-triazolo[4,3-a]quinoline is oxidized at low temperature with sodium periodate and ruthenium dioxide to give 5-chloro-2-(4H-1,2,4-triazol-4-yl)benzophenone.

Sources & evidence

ORD record
ord-818c3e7c31b64093a64ec0edac2520ed
Source dataset
uspto-grants-1976_12
Patent number
US04000151

Reaction notes

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