HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Nitrobenzaldehyde | HCID 11101 | — |
| Reactant | N,N-diethyl-6-methylnicotinamide | HCID 10081297 | — |
| Reactant | HCID 53931032 | HCID 53931032 | — |
| Product | Nicotinamide | HCID 936 | — |
Reaction Steps
Reaction of o-nitrobenzaldehyde (41.7 g., 0.276 mole) with N,N-diethyl-6-methylnicotinamide (53.1 g., 0.276 mole) in the presence of acetic anhydride (56.3 g., 0.552 mole) according to the method of L. Horwitz, J. Org. Chem., 21, 1039 (1956) provides 67.4 g. (75%) of N,N-diethyl-6-(o-nitrostyryl)-nicotinamide. Crystallization from acetonitrile affords the analytically pure nicotinamide having a melting point of 145°-147° C. (corr.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04000143 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-f6118c1f7c4f48f6a0fb2ad8b61d79b9 |
| Source note | uspto-grants-1976_12 |