Acetic Anhydride → HCID 20560054, compound

HRID 1974095Notes

Reaction equation

HRID 1974095 reaction equation
[NH2:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH3:13])=[CH:8][N:7]=1.[C:18](OC(=O)C)(=[O:20])C.NC1C=CC=CC=1CCC1C=CC=CN=1>C(O)=O>[CH2:12]([C:9]1[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]2[CH:14]=[CH:15][CH:16]=[CH:17][C:2]=2[NH:1][CH:18]=[O:20])=[N:7][CH:8]=1)[CH3:13]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 47154222-[2-(Pyridin-2-yl)ethyl]anilineHCID 20560024HCID 20560024, compound

Product 1

HCID 20560054HCID 20560054, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Reaction of 2-(o-aminophenethyl)-5 -ethylpyridine with acetic anhydride and formic acid according to the procedure described in Example 2 (b) for 2-(o-aminophenethyl)pyridine provides the formylated product 5-ethyl-2-(o-formamidophenethyl)pyridine which can be crystallized from isopropyl ether, m.p. 62° -63.5° C. (corr.).

Sources & evidence

ORD record
ord-81b548739d0f4926b66460a771ad8a8a
Source dataset
uspto-grants-1976_12
Patent number
US04000143

Reaction notes

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