4-Bromobenzoyl chloride → 4-Bromo-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide

HRID 1974112Notes

Reaction equation

HRID 1974112 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH2:11][C:12]1[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=1[CH2:14][CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][N:17]1[CH3:22]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:11][C:12]2[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=2[CH2:14][CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][N:17]2[CH3:22])=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 685154-Bromobenzoyl chlorideHCID 110852822-(2-Aminophenethyl)-1-methylpiperidine

Product 1

HCID 205599944-Bromo-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide

Procedure

Reaction of 4-bromobenzoyl chloride with 2-(o-aminophenethyl)-1-methylpiperidine according to the procedure of Example 114 affords 4-bromo-2'-[2-(1methyl-2-piperidyl)ethyl]benzanilide, m.p. 137.5° - 138.5° C. (corr.), from ethyl acetate.

Sources & evidence

ORD record
ord-cdf5ecbfd8dc4a4ab052c03e5c55eec7
Source dataset
uspto-grants-1976_12
Patent number
US04000143

Reaction notes

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