3-Phenylprop-2-enoyl chloride → N-{2-[2-(1-Ethylpiperidin-2-yl)ethyl]phenyl}-3-phenylprop-2-enamide
Reaction equation
[NH2:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[CH2:12][CH3:13].[C:18](Cl)(=[O:27])[CH:19]=[CH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:12]([N:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[CH2:5][CH2:4][C:3]1[CH:14]=[CH:15][CH:16]=[CH:17][C:2]=1[NH:1][C:18](=[O:27])[CH:19]=[CH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH3:13]Participants
3
Procedure
Reaction of 2-(2-aminophenethyl)-1-ethylpiperidine with cinnamoyl chloride according to the procedure of Example 25 provides 2'-[2-(1-ethyl-2-piperidyl)ethyl]cinnamanilide, m.p. 119.5° - 121.5° C. (corr.), from ethyl acetate and then acetonitrile.
Sources & evidence
- ORD record
- ord-f3cb67e53b974922bb6495b4c934741c
- Source dataset
- uspto-grants-1976_12
- Patent number
- US04000143
Reaction notes
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