Ethyl propiolate → HCID 70563746, compound

HRID 1974115Notes

Reaction equation

HRID 1974115 reaction equation
[C:1]([O:5]CC)(=O)[C:2]#[CH:3].[NH2:8][C:9]1[CH:23]=[CH:22][CH:21]=[CH:20][C:10]=1[CH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][N:14]1[CH3:19]>>[CH3:19][N:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH:13]1[CH2:12][CH2:11][C:10]1[CH:20]=[CH:21][CH:22]=[CH:23][C:9]=1[NH:8][C:1](=[O:5])[C:2]#[C:3][C:9]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:10]=1

Participants

3

Reactant 2

HCID 12182Ethyl propiolateHCID 110852822-(2-Aminophenethyl)-1-methylpiperidine

Product 1

HCID 70563746HCID 70563746, compound

Procedure

Reaction of ethyl propiolate with 2-(o-aminophenethyl)-1-methylpiperidine according to the procedure of Example 115 affords 2'-[2-(1-methyl-2-piperidyl)ethyl]phenylpropiolanilide, m.p. 104.5° - 106.5° C. (corr.), from ethyl acetate.

Sources & evidence

ORD record
ord-634ce1b844314610866ab07d4ac7e21e
Source dataset
uspto-grants-1976_12
Patent number
US04000143

Reaction notes

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