Acetic Acid → HCID 86734323, compound

HRID 1974123Notes

Reaction equation

HRID 1974123 reaction equation
N1C=CC=CC=1C[C:8]1[CH:24]=[CH:23][CH:22]=[CH:21][C:9]=1[NH:10][C:11](=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1.[C:25](O)(=O)[CH3:26]>[Pd]>[NH:10]1[CH2:9][CH2:8][CH2:24][CH2:23][CH:25]1[CH2:26][C:17]1[CH:16]=[C:15]([O:18][CH3:19])[CH:14]=[CH:13][C:12]=1[C:11]([NH:10][C:9]1[CH:8]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:20]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 205599902'-(2-Pyridylmethyl)-p-anisanilide

Product 1

HCID 86734323HCID 86734323, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Reduction of 2'-(2-pyridylmethyl)-p-anisanilide (4.65 g., 0.0146 mole) according to the procedure of Walker, J. Org. Chem., 27, 2966 (1962), in 150 ml. of acetic acid with 2.35 g. of 10% palladium on carbon catalyst affords 2'-(2-piperidylmethyl-p-anisanilide, m.p. 108° -109° C. (corr.), from benzene-hexane.

Sources & evidence

ORD record
ord-4095931469b64ccaa6aa0062d92e8b71
Source dataset
uspto-grants-1976_12
Patent number
US04000143

Reaction notes

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