Ammonia → Clonazolam

HRID 1974144Notes

Reaction equation

HRID 1974144 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[N:18]1[C:22]([CH3:23])=[N:21][N:20]=[C:19]1[CH2:24]Br.[NH3:27]>CO>[N+:15]([C:13]1[CH:12]=[CH:11][C:10]2[N:18]3[C:22]([CH3:23])=[N:21][N:20]=[C:19]3[CH2:24][N:27]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:9]=2[CH:14]=1)([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21488645HCID 21488645, compound

Product 1

HCID 12317881Clonazolam

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 8, 2'-chloro-5nitro-2-[3-(bromomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone is reacted with a saturated solution of ammonia in methanol to give 8-nitro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo- [4,3-a][1,4]benzodiazepine of melting point 231°-233° C.

Sources & evidence

ORD record
ord-c15ee8061e4243ab8371433f7b9b335b
Source dataset
uspto-grants-1976_12
Patent number
US04000153

Reaction notes

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