HCID 21488585, compound → HCID 21488590, compound

HRID 1974150Notes

Reaction equation

HRID 1974150 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]1[C:13](C)=[N:14][N:15]=[C:8]1[CH:7]=[C:6]2[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23].I([O-])(=O)(=O)=[O:27].[Na+]>[Ru](=O)=O>[Cl:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:6](=[O:27])[C:5]1[CH:4]=[C:3]([C:2]([F:25])([F:24])[F:1])[CH:12]=[CH:11][C:10]=1[N:9]1[CH:13]=[N:14][N:15]=[C:8]1[CH3:7]

Participants

4

Reactant 2

HCID 21488585HCID 21488585, compoundHCID 23667635Sodium periodate

Product 1

HCID 21488590HCID 21488590, compound

Reagents, catalysts & solvents 1

HCID 82848Ruthenium dioxideCatalyst

Procedure

In the manner given in Example 3, 7-(trifluoromethyl)-1-methyl-5-(o-chlorophenyl)-s-triazolo[4,3-a]quinoline is oxidized at low temperature with sodium periodate and ruthenium dioxide to give 2'-chloro-5-(trifluoromethyl)-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone.

Sources & evidence

ORD record
ord-4ed8ef79c0e2465094352bd1fb53aabe
Source dataset
uspto-grants-1976_12
Patent number
US04000153

Reaction notes

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