Phosphorus tribromide → HCID 21488672, compound

HRID 1974162Notes

Reaction equation

HRID 1974162 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:24])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH3:21])=[N:19][N:18]=[C:17]1[CH2:22]O.P(Br)(Br)[Br:26]>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:24])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH3:21])=[N:19][N:18]=[C:17]1[CH2:22][Br:26]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 21488659HCID 21488659, compound

Product 1

HCID 21488672HCID 21488672, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In the manner given in Example 5, 2'-fluoro-5-chloro-2-[3-(hydroxymethyl)-5-methyl-4H-1,2,4-triazol-4-yl]-benzophenone is treated with phosphorus tribromide in chloroform to give 2'-fluoro-5-chloro-2-[3-(bromomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-5093ab8048a44c809c7be2949a76f4cc
Source dataset
uspto-grants-1976_12
Patent number
US04000153

Reaction notes

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