反应详情

温度

20 °C

7.6 g (32.74 mmol) of trichloroisocyanuric acid are added, over 1 hour, to a solution, maintained at reflux, of 10 g of trimethylpyrazine (81.85 mmol) in 820 ml of dichloroethane. The reaction mixture is refluxed for 6 hours and then cooled to 20° C., stirred for a further 12 hours and filtered. The filtrate is concentrated under reduced pressure, taken up in 200 ml of ethyl ether, filtered again and then concentrated under reduced pressure. 9.6 g of methyldimethylpyrazine chloride are recovered in the form of a mixture, which is used without further purification in the following step.

1. temperaturemaintained
2. temperatureThe reaction mixture is refluxed for 6 hours
3. filtrationfiltered
4. concentrationThe filtrate is concentrated under reduced pressure
5. filtrationfiltered again
6. concentrationconcentrated under reduced pressure
7. custom9.6 g of methyldimethylpyrazine chloride are recovered in the form of a mixture, which
8. customis used without further purification in the following step