HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-(N,N-Dibenzylglycyl)-2-(heptyloxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Iodoheptane | HCID 20274 | — |
| Reactant | 5-((Bis(benzyl)amino)acetyl)salicylamide | HCID 121727 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 5-(N,N-Dibenzylglycyl)-2-(heptyloxy)benzamide | HCID 21488889 | 99.8% |
Reaction Steps
A mixture of potassium carbonate (3.73 g), 5-(N,N-dibenzylglycyl) salicylamide (10 g) and 1-iodo heptane (7.5 g) in butanone (200 ml) was stirred and heated under reflux for 24 hours. The solid was filtered off and the filtrate was evaporated. The residue was partitioned between ethyl acetate and water. The dried (MgSO4) ethyl acetate solution was evaporated to give a yellow oil (12.6 g) which crystallised twice from isopropanol to yield the ether (6.3 g) m.p. 97.5°-98°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04000192 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-eded272c926b42ee9a7bfb331ade1567 |
| Source note | uspto-grants-1976_12 |