Sodium hydride → HCID 21821762, compound

Participants

Reaction Steps

Benzimidazo[2,1-b]quinazolin-12(6H)one, 7.05 g. in 200 ml. of dry dimethylformamide was converted to the sodium derivative with sodium hydride according to the procedures described in previous examples and 2,4-dimethylbenzoyl chloride, 5.8 g. in 25 ml. of dimethylformamide were added dropwise with vigorous stirring. The reaction mixture was stirred for an additional hour and then poured into ice water. The precipitate which formed was filtered, washed with water, dried and twice recrystallized from benzene to yield 6-(2,4-dimethylbenzoyl)benzimidazo[2,1-b]quinazolin-12(6H)one as a crystalline solid melting at about 213°-214° C.

Provenance & Evidence