Water → HCID 86734343, compound

Participants

Reaction Steps

A solution of 5-(N,N-dibenzylglycyl)-2-(2-hydroxyethoxy)-benzamide (see Example 6(a)) (2.5 g) in acetic anhydride (10 ml) and acetic acid (10 ml) was heated at 100° for 1.25 hours, cooled, and poured into water. After being allowed to stand for 2 days at room temperature the aqueous solution was basified with sodium bicarbonate and extracted with ethyl acetate (3 × 100 ml). The dried extract was evaporated and the ether-soluble portion of the residue treated with ethereal hydrogen chloride. The precipitate (1.6 g) in water (50 ml) was basified with sodium bicarbonate solution and was extracted with ether (3 × 50 ml). The dried extracts were evaporated to give a solid m.p. 120°-128° (from ethyl acetate).

Provenance & Evidence