4-Chlorotoluene → HCID 53644391, compound

HRID 1974339Notes

Reaction equation

[C:1]1([CH3:8])[CH:6]=[CH:5][C:4](Cl)=[CH:3][CH:2]=1.[NH2:9][C@@H:10]([C:21]([OH:23])=[O:22])[CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][CH:13]=1>>[C:1]1([CH3:8])[CH:6]=[CH:5][C:4]([NH:9][C@@H:10]([C:21]([OH:23])=[O:22])[CH2:11][C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 78104-Chlorotoluene

HCID 9060D-Tryptophan

Product 1

HCID 53644391HCID 53644391, compoundYield 82%

Procedure

The same procedure is used as in Example 1, p-toluyl chloride and D-tryptophane being used. Yield 82%. Melting point 146.5° to 147.5° C.

Sources & evidence

ORD record: ord-3b9173589b384e978eac77b560dda6e7
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04000297

Reaction notes

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