HCID 178418361, compound → HCID 178441146, compound

HRID 1974349Notes

Reaction equation

HRID 1974349 reaction equation
[C:1]([C:5]1[C:13]2[NH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[N:10][C:9]=2[CH:8]=[C:7]([N+:18]([O-])=O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[H][H]>C(O)C.[Pt]=O>[C:1]([C:5]1[C:13]2[NH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[N:10][C:9]=2[CH:8]=[C:7]([NH2:18])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178441181HCID 178441181, compound

Product 1

HCID 178441146HCID 178441146, compoundYield 160%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

4-tert-Butyl-6-nitro-2-trifluoromethylbenzimidazole (6.0 grams of crude) was dissolved in 100 milliliters of ethanol and a small amount of platinum oxide was added. The reaction mixture was then placed in a pressure container and hydrogenated until hydrogen uptake ceased. The reaction mixture was filtered and solvent removed to yield 8.6 grams of crude 4-tert-butyl-6-amino-2-trifluoromethylbenzimidazole, as a brown oil.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customsolvent removed

Sources & evidence

ORD record
ord-68c60e4b4c8c4dc09da46ec1dc47249d
Source dataset
uspto-grants-1976_12
Patent number
US04000295

Reaction notes

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