反应详情

温度

60 °C

A mixture of 3,5-diphenyl-4-pyrazolol (10 g, 0.042 mole), sodium methoxide (2.27 g, 0.042 mole) and methanol (60 ml) is heated at 60° C for 2 hours. Then 1-bromopropane (5.17 g, 0.042 mole) is added slowly (5 minutes) at 60° C. The reaction mixture is then held at 60° C until the reaction is complete by tlc. The mixture is poured into water and the solid formed isolated by filtration. Recrystallization of the solid from acetonitrile affords white crystals, 7.4 g (63%), melting point 142°-142.5° C.

1. customis then held at 60° C until the reaction
2. customthe solid formed
3. customisolated by filtration
4. customRecrystallization of the solid from acetonitrile
5. customaffords white crystals, 7.4 g (63%), melting point 142°-142.5° C.