Ammonia → HCID 20316742, compound

HRID 1974385Notes

Reaction equation

HRID 1974385 reaction equation
N.[C:2]1(=[O:18])[N:6]([CH:7]([CH3:12])[CH2:8][CH2:9][C:10]#[N:11])[C:5](=[O:13])[C:4]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:3]12.[SH2:19]>CO>[C:5]1(=[O:13])[N:6]([CH:7]([CH3:12])[CH2:8][CH2:9][C:10]([NH2:11])=[S:19])[C:2](=[O:18])[C:3]2=[CH:17][CH:16]=[CH:15][CH:14]=[C:4]12

Participants

5

Reactant 3

HCID 222AmmoniaHCID 402Hydrogen SulfideHCID 21489471HCID 21489471, compound

Product 1

HCID 20316742HCID 20316742, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Liquid ammonia (20 g) and 4-phthalimidovaleronitrile (67 g) is added to a cooled solution of hydrogen sulphide (50 g) in methyl alcohol (500 ml). The sealed reaction vessel is the heated at 40° for 3 days with stirring. Concentration followed by recrystallization from isopropyl acetate yields 4-phthalimidothiovaleramide, m.p. 143°-146° C.

Workup

  1. customThe sealed reaction vessel
  2. temperatureheated at 40° for 3 days
  3. concentrationConcentration
  4. customfollowed by recrystallization from isopropyl acetate

Sources & evidence

ORD record
ord-23e4ec401427432b8ea7b19e45cd8c06
Source dataset
uspto-grants-1976_12
Patent number
US04000302

Reaction notes

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