1-Cyano-2,3-dimethylisothiourea → HCID 178513029, compound

HRID 1974407Notes

Reaction equation

HRID 1974407 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[S:7][CH:8]=[CH:9][N:10]=1.[C:11]([NH:13]C(=NC)SC)#[N:12]>>[S:7]1[CH:8]=[CH:9][N:10]=[C:6]1[CH2:5][S:4][CH2:3][CH2:2][NH:1][C:11]([NH2:13])=[NH:12]

Participants

3

Reactant 2

HCID 1111031-Cyano-2,3-dimethylisothioureaHCID 129234032-[(Thiazol-2-yl)methylthio]ethylamine

Product 1

HCID 178513029HCID 178513029, compound

Procedure

Reaction of [(2-aminoethyl)thiomethyl]thiazole (from the dihydrobromide 20.2 g) with N-cyano-N',S-dimethylisothiourea (7.75 g) by a procedure similar to that described in Example 75, afforded N-cyano-N'-methyl-N"-[(2-(2-thiazolylmethylthio)ethyl]guanidine, m.p. 120°-122.5°, following chromatography on silica gel with alcohol.

Sources & evidence

ORD record
ord-2d55dde51cc74388910383c783367ace
Source dataset
uspto-grants-1976_12
Patent number
US04000302

Reaction notes

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